"In the study, published today in Cell Reports, they found that nerve damage changes epigenetic marks on some of the genes in these immune cells. Epigenetics is the process that determines which gene is expressed and where. Some epigenetic signals have direct functional consequences, while others are just primers: flags that indicate a potential to act or be modified.
The cells examined in this King's study still behaved as normal, but the existence of these novel epigenetic marks may mean that they carry a 'memory' of the initial injury."
As a sufferer of chronic pain, this is quite interesting. Sadly, I suspect it may take several years before it may help lead to treatment plans.
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